| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cf32b60391b469c41e86c353437f5751 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2500-60
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2510-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2523-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P21-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P21-005
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-02 |
| filingDate |
2016-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1764c96e37a7411c86c14ea059c152cd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bc9bd4ddca454d96f00862ff7847e325
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aee7660730a0a29735905de0215a414d |
| publicationDate |
2016-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
JP-2016214254-A |
| titleOfInvention |
Improved cell culture medium |
| abstract |
A method for improving large-scale production of polypeptides in CHO cell culture is provided. CHO cells are grown at a first temperature for at least 3 days, then the temperature is varied to a second temperature that is about 1 ° C. to about 8 ° C. lower than the first temperature, and the cells are For at least two more days, allowing the cells to grow at the first pH value for at least two days, and then changing the pH to a second pH value that is about 0.05 to about 1 pH unit lower than the first pH value. , Allowing the cells to grow at the second pH for at least one day. [Selection figure] None |
| priorityDate |
2010-04-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |