| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_04c5979945d3395574b12070112e9071
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0fb7f1e202fdcfa3cbb52cd530bbc581
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2b28f16165a64d9a40cf3407465f75f3 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4172
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K8-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K8-66
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61Q19-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61Q1-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-185
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-198
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-196
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-197 |
| filingDate |
2015-04-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d53ea3af88ca0399e4020b116ef9e53c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0b6b70663b712bb5f824f1dcd4346932 |
| publicationDate |
2016-12-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
JP-2016204284-A |
| titleOfInvention |
Tyrosinase activity inhibitor and topical skin preparation |
| abstract |
Provided are a tyrosinase activity inhibitor capable of effectively suppressing tyrosinase activity, a cosmetic preparation excellent in whitening effect, and a skin external preparation useful as a quasi-drug. Tyrosinase activity in which α-lipoylamino acid metal chelate compound (wherein the metal is zinc, cobalt or iron) or a pharmacologically acceptable salt thereof (A) and human manganese SOD (B) Inhibitor. The use ratio R is preferably 0.001 to 1,500 when defined as R = [unit concentration of unit (B) (unit / mL) / concentration of component (A) (μg / mL)]. . An external preparation for skin containing both the components (A) and (B) as active ingredients for suppressing tyrosinase activity. The tyrosinase activity inhibitor, wherein the component (A) is histidine dithiooctanamide (Na / Zn) and the human manganese SOD (B) is produced by recombinant synthesis using Escherichia coli or yeast. [Selection figure] None |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2019100097-A |
| priorityDate |
2015-04-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |