abstract |
A pharmaceutical composition for use in the treatment of a disease or condition selected from pseudobulbar affect and neuropathic pain, and methods of use thereof. Compositions comprising a morphinan compound of formula (I) and methods of use to treat diseases and conditions that are beneficially treated by administration of a sigma 1 receptor agonist also having NMDA antagonist activity. (R 1 is CD 3 , CHD 2 or CH 2 D; R 2 is CH 2 D or CHD 2 ) [Selection figure] None |