| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2a129cde39c83aa3792d57f690f82bf7 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-10 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-1787
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-08 |
| filingDate |
2016-06-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a0a0f39aa75e4e9318e366023b10997b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_70c3ce58d922693f79c3e93199f30ad2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ca2a17a12253e0198e898faa01873d9d |
| publicationDate |
2016-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
JP-2016199553-A |
| titleOfInvention |
Epilepsy treatment |
| abstract |
A method for treating a patient suffering from epilepsy is provided. A therapeutic agent for epilepsy containing a PSD-95 inhibitor that inhibits the binding of a PDZ-binding ligand to the PDZ domain of PSD-95. The inhibitor is a chimeric peptide having an amino acid sequence consisting of 3-25 amino acids from the C-terminus of the NMDA receptor or PDZ domains 1 and / or 2 from the PSD-95 receptor, and binds to the internalization peptide It is a chimeric peptide containing an active peptide. The inhibitor is Tat-NR2B9c. The inhibitor is F-Tat-NR2B9c, which has the following structure. As shown in FIG. 4A, Tat-NR2B9c is neuroprotective in the pre-CA1 region of the hippocampus. [Selection] Figure 4A |
| priorityDate |
2008-05-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |