| abstract |
[PROBLEMS] To provide a novel peptidomimetic macrocycle compound excellent in metabolic stability and cell permeability and free of a potential toxic metal, its preparation method and use method, amino acid analog, macrocycle compound-forming linker, and kit useful for its production Offer. A peptidomimetic macrocycle comprising a structure represented by formula (I). (A, C, D and E are each independently a natural or non-natural amino acid; B is a natural or non-natural amino acid or amino acid analog; v is an integer of 1-1000; w is an integer of 1-1000; x is 0-10. Y is an integer of 0 to 10; z is an integer of 0 to 10; x + y + z is at least 3) [Selection] Figure 1 |