| abstract |
Disclosed are selective myostatin antagonists (including antibodies) against myostatin called growth / differentiation factor 8 (GDF-8), nucleic acids encoding them, and methods of making and using them. An isolated myostatin specific antibody comprising at least one light chain and at least one heavy chain, wherein the light chain comprises a constant region and three complementarity determining regions (CDRs). An isolated myostatin-specific antibody, wherein the heavy chain comprises a constant region and a variable region comprising three CDRs, wherein the light and heavy chain CDRs have a specific sequence. [Selection figure] None |