| abstract |
Disclosed are methods and compositions for treating complement related disorders, the present disclosure provides, inter alia, compositions comprising inhibitors of human complement, and for treating or preventing complement related disorders. It relates to the use of this composition in a method. In some embodiments, the inhibitor is administered to the patient over time. In some embodiments, the inhibitor is administered to the patient in an amount and frequency that maintains systemic complement inhibition and prevents rapid progression. In some embodiments, the composition comprises human complement component C5 protein or a fragment thereof, eg, an antibody that binds to C5a or C5b, or an antigen-binding fragment thereof. [Selection figure] None |