abstract |
The present invention provides a pharmaceutical composition containing interleukin-12 (IL-12) for enhancing hematopoietic function. (A) 0.1 to 50 μg / ml IL-12 or an IL-12 variant with hematopoietic activity; (b) 10 to 500 mM of at least one stabilizer which is a salt; (c) 0 0.001% to 20% of a surfactant that is a poloxamer; and (d) water, wherein the IL-12 or IL-12 variant is solubilized and has a pH of 3.0 to 9.0 A pharmaceutical composition having The pharmaceutical composition is preferably formulated for intradermal, intramuscular, intraperitoneal, intravenous, subcutaneous, intranasal, epidural and / or oral administration. The salt is preferably sodium chloride. [Selection figure] None |