abstract |
[PROBLEMS] To suppress the transition to inflammation (redness, thermal sensation, swelling, pain) by controlling the activation of epidermal cells by IL-8 gene expression, NO production, etc. caused by damage-related molecular patterns (DAMPs) Providing the composition. A perilla extract or a hornon extract that suppresses IL-8 gene expression and NO production in epidermal cells activated by DAMPs stimulation. A composition for external application to the skin for suppressing inflammation transfer comprising at least one of an IL-8 gene expression inhibitor or an NO production inhibitor comprising the extract as an active ingredient. [Selection figure] None |