abstract |
PROBLEM TO BE SOLVED: To provide a solution to long-standing clinical problems of autoimmunity, allergy / asthma and chronic or inappropriate inflammation in the body, such as inflammation resulting in tissue / organ damage and destruction. Antigens, mobilization compositions, and tolerances that use biomaterial systems, such as gel scaffolds, in vivo to mobilize immune cells to promote their activation to a non-inflammatory phenotype resulting in suppression of inflammation Scaffold composition containing the raw material. Preferably, a composition comprising a Th1 promoter. The tolerogen includes thymic stromal lymphocyte formation factor, dexamethasone, vitamin D, retinoic acid, rapamycin, aspirin, transforming growth factor β, interleukin-10, vascular endothelial growth factor, and the like. , GM-CSF, FMS-like tyrosine kinase 3 ligand, N-formyl peptide, fractalkine or monocyte chemotactic protein-1. The composition is useful for reducing the severity of autoimmunity, chronic inflammation, allergies and periodontal disease. [Selection figure] None |