| abstract |
Provided is an Fc region useful for site-specific conjugation to various drugs. An Fc region of an antibody comprising a substitution at position 339, the substitution comprising a substitution with an amino acid selected from cysteine, lysine, tyrosine, histidine, selenocysteine, and selenomethionine, wherein the heterologous substance is Fc region bound to a replacement amino acid. The Fc region is selected from IgG1, IgG2, IgG3, or IgG4 isotype. Used in the manufacture of drugs for treating cancer, autoimmunity, inflammatory or infectious diseases or disorders, and drugs for detecting them. [Selection] Figure 1 |