| abstract |
The present invention provides a compressed tablet with reduced pH sensitivity of atazanavir sulfate, a prescription drug for the treatment of HIV. The compressed tablet contains an acidifying agent in addition to atazanavir sulfate. The acidifying agent is a compressed tablet selected from citric acid, tartaric acid, fumaric acid, ascorbic acid, or a mixture thereof. Preferably, the compressed tablet further comprises a settling retarder selected from polyvinylpyrrolidone, polyvinylpyrrolidone-vinyl acetate, hydroxypropylcellulose, hydroxypropylmethylcellulose, hydroxypropylmethylcellulose acetate succinate or mixtures thereof. [Selection figure] None |