| abstract |
[PROBLEMS] To provide a long-term residual tissue useful for a disease requiring treatment with a long-term residual tissue swelling material such as vesicoureteral reflux disease, which is highly safe in the living body and has long-term durability and shape maintenance. Providing bulging material. A glycosaminoglycan (GAG) cross-linked product, which is obtained by introducing a SPAAC type reactive group bonded to a carboxyl group of a GAG molecule by an amide bond and further performing a SPAAC reaction: -CONH- GAG crosslinked body which has R1-X-R2-NHCO- or -CONH-R3-X-R4-X'-R5-NHCO-. [Wherein, R 1 to R 5 are the same or different and each represents an alkylene group, an alkenylene group, or an alkynylene group, and —CH 2 — in the group represents> C═O, —CONH—, arylene, —O—, Or may be replaced by -S-; X and X 'are the same or different and each represents a divalent group having a specific 1,2,3-triazole ring. ] [Selection figure] None |