| abstract |
Disclosed are fine particles having an adsorptive surface, a method for producing such fine particles, and use thereof. The microparticles include a polymer (eg, poly (α-hydroxy acid), polyhydroxybutyric acid, polycaprolactone, polyorthoester, polyanhydride, etc.) and are cationic, anionic or nonionic It is formed using a surfactant. The surface of the microparticles efficiently adsorb biologically active macromolecules (eg, DNA, polypeptides, antigens and adjuvants). Oil droplet emulsion compositions having metabolizable oils and emulsifiers are also provided. Also provided is an immunogenic composition having an immunostimulatory amount of an antigenic substance and an immunostimulatory amount of an adjuvant composition. [Selection figure] None |