| abstract |
Disclosed is a compound that exhibits phosphodiesterase inhibitory activity, such as PDE4 inhibitory activity, and is useful in the treatment of inflammatory diseases and disorders. A compound represented by formula (I) or a pharmaceutically acceptable salt, hydrate or solvate thereof. [m and n are each independently 0 or 1; R 1 and R 2 are selected from O, S, —S (O) — or —S (O) 2 — together with the carbon atom to which they are attached. A heterocyclic ring containing one or two heteroatoms; R3 is —CHF2, —CF3, —OCHF2, —OCF3, —SCHF2 or —SCF3; X is a bond, —CH2— or —NH—; A Is aryl etc.] [selection figure] None |