| abstract |
An agonistic anti-PD-1 antibody for enhancing signal transduction of a programmed death 1 (PD-1) protein, also known as CD279, to regulate inflammatory diseases and the like, and a drug containing the anti-PD-1 antibody . A variable domain of a heavy chain having a specific sequence and a mouse monoclonal antibody that binds to human PD-1 comprising a variable domain of a light chain having a specific sequence are transplanted into the human antibody framework. Humanized agonist antibodies that bind to human PD-1. A humanized agonist antibody that binds to human PD-1 comprising a heavy chain, wherein the heavy chain framework region is preferably a human subpopulation sequence VH 1-3 1-4 + JH (derived from a specific sequence) Agonist antibody. [Selection figure] None |