| abstract |
In a concentrator that concentrates an aqueous protein solution produced by filtering body cavity fluid, a high protein recovery rate can be ensured while realizing high-concentration concentration. When the separation membrane 60 of the concentrator 22 is converted to a hollow fiber membrane having a porosity of 60% or more and 80% or less and a liquid level rise value of the separation membrane measured by the capillary ascending method, an inner diameter of 200 μm. When the concentration step of obtaining a concentrated aqueous solution of protein by passing a 3 g / dL protein aqueous solution at a flow rate of 50 mL / min, the following conditions (1) and (2) are satisfied. Has been. (1) The maximum transmembrane pressure difference when 5 L of protein aqueous solution stock is concentrated is 500 mmHg or less, (2) The transmembrane pressure difference when 2 L of protein aqueous solution is concentrated is A, and 5 L of protein aqueous solution is concentrated When the transmembrane pressure difference is B, B / A ≦ 1.6. [Selection] Figure 3 |