| abstract |
A CD37-binding molecule and an immune complex thereof are provided. CD37 agents that bind to CD37, such as, but not limited to, antibodies, to deplete B cells (eg, non-cancerous B cells) to treat autoimmune and inflammatory diseases And methods of using the immune complexes are disclosed. Further disclosed are light and heavy chain variable region sequences that specifically bind to CD37. Contacting a cell population comprising non-cancerous B cells with an antibody or antigen-binding fragment thereof that specifically binds to CD37, wherein said antibody or fragment thereof can induce apoptosis in vitro in the absence of a cross-linking agent Also provided are methods of depleting B cells. [Selection] Figure 4 |