| abstract |
It is an object of the present invention to provide binding competent albumin and albumin related polypeptides, and complexes thereof having at least a portion, and polynucleotides encoding them. [MEANS FOR SOLVING PROBLEMS] Based on the three-dimensional structure of albumin, the present inventors designed a mutant polypeptide (mutant protein) having a free thiol group and having one or more cysteine residues (hereinafter referred to as "thioalbumin"). "). The variant polypeptide is linked to a binding partner, for example a biologically active compound, via the sulfur atom of the cysteine residue. [Selection figure] None |