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filingDate 2016-01-07-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2016-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-2016145191-A
titleOfInvention HAT acetylated promoter and use of the composition in promoting immunogenicity
abstract Increased presentation of major histocompatibility complex (MHC) class I surface molecules detected by cytotoxic T lymphocyte cells via increased antigen processing-related transporter (TAP) -1 expression Thus, the provision of methods and compositions for enhancing the immunogenicity of cells lacking TAP-1 expression. A pharmaceutical composition for use in treating a TAP-1-deficient cancer comprising a histone deacetylase inhibitor and a suitable adjuvant or carrier. The pharmaceutical composition further comprising a vaccine formulation. A pharmaceutical composition wherein the TAP-1-deficient cancer expresses a herpesvirus antigen or expresses a papillomavirus antigen. [Selection figure] None
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