| abstract |
5- (2,6-di-4-morpholinyl-4-pyrimidinyl) -4-tri having phosphatidylinositol 3-kinase (PI3K) inhibitory properties and particularly effective for the prevention or treatment of proliferative diseases Provision of a method for producing fluoromethylpyridin-2-amine (5) and a salt thereof (5a). For example, Suzuki introduces a compound 4 obtained by introducing two morpholino groups into 2,4,6-trichloropyrimidine and converting it to a boronic ester, and a compound 4a obtained by bromination of compound 4b. A production method comprising a method of reacting under coupling conditions to give compound 5 and then forming a salt to obtain 5a. [Selection] Figure 2 |