abstract |
The present invention relates to a cytotoxic conjugate specific to a CA6 antigen on a Mucl mucin receptor and a method of using the same. A cytotoxic conjugate comprising a cell binding agent and a cytotoxic agent. A therapeutic composition comprising the conjugate, a method of using the conjugate for inhibiting cell proliferation and treating a disease, and a kit comprising a cytotoxic conjugate. The cell binding agent is a monoclonal antibody that recognizes and binds to a CA6 glycotope and an epitope-binding fragment thereof. A cytotoxic conjugate, wherein the cytotoxic substance is a compound selected from a maytansinoid compound or a taxoid compound exemplified by formula (II), a CC-1065 compound, or the like. [Selection figure] None |