abstract |
The present invention provides a composition for treating IFN-λ dependent diseases by inducing IFN-λ production in CD8 + and / or eCD8 + conventional dendritic cells (cDC). The present invention is selected from the group consisting of dsDNA which is HSV-1 or parapoxvirus, dsRNA which is Semliki Forest virus (SFV) or mouse hepatitis virus (MHV), poly IC, poly AU, poly ICLC, poly dAdT. A composition comprising a double-stranded (ds) nucleic acid, wherein the eCD8 + cDC expresses Cle9a and / or Necl2. [Selection figure] None |