| abstract |
[PROBLEMS] To establish a technique for producing antigen-specific CD4-positive T cell cloned animals, and to provide non-human mammals that react with various antigens that are suggested to be related to immune allergic diseases such as mites and cedar pollen. about. A non-human mammal and its progeny obtained by a somatic cell nuclear transfer method using the nucleus of a CD4 positive T cell specific to room dust, insect antigen, pollen antigen, dietary antigen, etc. as a nuclear donor, and A method for preparing a non-human mammal, wherein a nucleus of a CD4 positive T cell is used as a nuclear donor and somatic cell nuclear transfer is performed. [Selection figure] None |