| abstract |
A tablet unit dosage form for treating pain, inflammation, cardiovascular disease, etc. and reducing the onset of dyspepsia related symptoms in patients at risk of developing non-steroidal anti-inflammatory drug-related ulcers Of a pharmaceutical composition. A core includes two or more layers, a) the core includes aspirin or a pharmaceutically acceptable salt thereof, and b) a first layer surrounds the core and has a pH of 3.5 or less. And a coating that does not dissolve in an aqueous medium at a temperature of 37 ° C., and c) at least one second layer brings the subject's gastric pH to at least 3.5 after administration of the one or more unit dosage forms An effective amount of omeprazole or a pharmaceutically acceptable salt thereof, wherein the second layer comprises the first layer, which dissolves readily when the dosage form is placed in an aqueous medium regardless of pH. A pharmaceutical composition used to surround the coating of the layer and be administered continuously for at least 14 days. [Selection figure] None |