| abstract |
The present invention provides a stable and high-concentration antibody preparation of an anti-IL-7R antibody that solves the problems from preparation preparation to delivery to a patient due to the high viscosity of the antibody preparation. A composition having an anti-IL-7R antibody concentration of about 100 to about 300 mg / ml, further comprising arginine HCl or NaCl, sucrose, a buffer, a chelating agent, and a polysorbate, wherein the pH is A composition which is about 6.5 to about 7.5. Preferably, the concentration of sucrose is about 1 to about 100 mg / ml, the polysorbate is polysorbate 80, the concentration is about 0.01 to about 0.3 mg / ml, the buffer is a histidine buffer, and the concentration is about a 1.0 to about 30 mM, chelating agent is from about 0.01 to about 0.3 mg / ml in EDTANa 2, composition. [Selection] Figure 1 |