| abstract |
PROBLEM TO BE SOLVED: To identify a specific torque teno (TT) virus sequence clearly associated with a disease such as cancer or autoimmune disease, and to provide a means for diagnosis and therapy. For the diagnosis and prevention and treatment of diseases such as cancer and autoimmunity, (a) specific TT virus sequences, and (b) autonomously replicable cancer and autoimmune diseases. A reconstituted TT virus polynucleic acid having a nucleotide sequence encoding a polypeptide exhibiting homology to a related mammalian protein. Preferably, the reconstituted TT virus polynucleic acid is present as a single-stranded or double-stranded extrachromosomal episome. Furthermore, a TT virus polynucleic acid that is preferably single-stranded DNA. [Selection figure] None |