| abstract |
【Task】 An object of the present invention is to provide a pharmaceutical composition containing a novel α-substituted glycinamide derivative, or a pharmaceutically acceptable salt thereof, and a pharmaceutical use thereof. [Solution] The present invention relates to the general formula (I) having a TRPM8 inhibitory action. [Chemical] [ Wherein , A 1 is C 6-10 aryl, A 2 is C 6-10 aryl, X is CH, etc. Y is —CR 1 R 2 —, etc. 1 and R 2 are independently a hydrogen atom, R 3 and R 4 are independently a halogen atom, and n is 1 or 2, or a compound thereof A pharmaceutical composition containing a pharmacologically acceptable salt is provided. Furthermore, the pharmaceutical composition of the present invention can be used as a therapeutic or prophylactic agent for diseases or symptoms caused by afferent nerve hyperexcitation or disorder. [Selection figure] None |