| abstract |
Provided are engineered immunoglobulin Fc polypeptides. Methods and compositions comprising polypeptides having non-glycosylated antibody Fc domains. In certain embodiments, the polypeptide has an unglycosylated Fc domain that includes one or more substitutions compared to a native Fc domain. Furthermore, some embodiments include Fc domains that bind to some Fc receptors but not others. For example, polypeptides are provided that have an unglycosylated Fc domain that selectively binds to FcγRIIa, but is significantly reduced for binding to highly homologous FcγRIIb receptors. Further, methods for promoting antibody-dependent cell-mediated cytotoxicity (ADCC) using a polypeptide having a modified unglycosylated Fc domain and a second non-Fc binding domain and A composition is provided. [Selection figure] None |