| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_69ece09bafee7e0c49d1f7951a3faa2c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2cb03ff309c31e766cf428b88c1dd9a6 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-726 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-74
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-705 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-167
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-496
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4545
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-705 |
| filingDate |
2015-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cdc9189942534d6c2b950a23980d73ee
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3bb4fe038b7088152e4adec350b7cf28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a5bb81c551fd7dd06b122b0eb3a1c22d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_95920cb15e02c34c3810079531254394 |
| publicationDate |
2016-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
JP-2016073276-A |
| titleOfInvention |
Mutant SMOOTHENED AND METHOD OF USING THE SAME |
| abstract |
PROBLEM TO BE SOLVED: To provide a method for diagnosing a patient who can be resistant to treatment by either natural variation of SMO genotype or acquired mutation and resistance. An isolated nucleic acid molecule and probe having a mutation at amino acid position 473 that is at least 95% identical to a specific sequence and encodes a mutant SMO protein. Use of an isolated mutant SMO protein and an antibody conjugated with a cytotoxic agent that specifically binds to the mutant SMO protein. Furthermore, amplifying a nucleic acid corresponding to the carboxy terminus of the transmembrane domain 6 of SMO suspected of containing a mutation or a fragment thereof, and the electrophoretic mobility of the amplified nucleic acid to the corresponding wild-type SMO gene or A method of detecting a mutated SMO gene in a sample comprising comparing the electrophoretic mobility of the fragment. [Selection figure] None |
| priorityDate |
2009-09-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |