| abstract |
To provide a stable preparation of linaclotide. The present invention relates to a stable pharmaceutical composition comprising linaclotide or a pharmaceutically acceptable salt thereof, and various methods and processes for preparing and using the composition. In some embodiments of the present invention, a stable pharmaceutical composition is provided, the composition comprising linaclotide, a cation or salt thereof, and a sterically hindered amine selected from meglumine, histidine or mixtures thereof, and Depending on the polymer. [Selection figure] None |