| abstract |
Disclosed are compositions containing phorbol esters and methods of use thereof in the treatment of cytopathic diseases. Cytopathic diseases are caused by a variety of causes such as viral infections such as HIV and AIDS, or tumor formation in mammalian subjects, and the uses and compositions of the present invention provide new inhibition of HIV infection, viral expression from latent proviruses. Promote, HIV-induced cytopathic inhibition, HIV receptor downregulation, Th1 cytokine expression increase, Th2 cytokine expression decrease, ERK phosphorylation increase, malignant cell apoptosis induction, remission induction, remission maintenance, chemotherapeutic agent, It is also effective in alleviating the symptoms of cytopathic diseases and the opportunistic infections associated with those diseases. The use of a specific phorbol ester or a pharmaceutically acceptable salt thereof for the manufacture of a therapeutic agent for a cytopathic disease. [Selection figure] None |