| abstract |
Encapsulation of nucleic acid with high efficiency, high drug: lipid ratio, protection of encapsulated nucleic acid from degradation and clearance in serum, suitable for systemic delivery, Providing constituent lipids of suitable lipid-therapeutic nucleic acid compositions that enable delivery. A lipid having the following structure. (R 1 and R 2 are each independently an optionally substituted C 10 -C 30 alkenyl or the like, or -linker-ligand; R 3 is H, optionally substituted C 1 -C 10 alkyl, optionally substituted C in 2 -C 10 alkenyl, optionally substituted C 2 -C 10 alkynyl, Arukiruhetoro ring, alkyl phosphates, alkyl phosphorothioates, alkyl phosphorodithioate, alkylphosphonate, alkylamines, hydroxy Alkyl, ω-aminoalkyl, ω- (substituted) aminoalkyl, etc .; E is C (O) O or OC (O)) [Selection figure] None |