http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2016042868-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b453ed400e069c7ce1d259bf75fb9fc7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a036f2084bcde7157a34fd277d07b276 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-02 |
| filingDate | 2015-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cb6b37651d473fa7fdfa9f753a87be7d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cc1bbb02723d99a1415858b523faec19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b3c5302c114b5984559e0cba825427e2 |
| publicationDate | 2016-04-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2016042868-A |
| titleOfInvention | Adult T-cell leukemia model cells and animals, and methods for producing them |
| abstract | The present invention provides a standard ATL model cell and a model animal, in which the degree of gene mutation is easy to control and the quality is easy to equalize. Provided are model cells and animal models that have actual ATL onset factors and reflect the general pathology of ATL. Provided are ATL model cells and animal models with higher production efficiency and shorter time to production. A T cell into which an HBZ gene, an apoptosis-suppressing gene, and a TCR signal-related gene are introduced, and CDKN2A is knocked out as necessary. An ATL model animal into which the cells are introduced. A method for evaluating an ATL therapeutic or prophylactic agent using these cells and animals. [Selection figure] None |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107216371-A |
| priorityDate | 2014-08-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 187.