| abstract |
Provided is a covalent bond between a peptide which is Factor IX and a water-soluble polymer. A covalent bond between a peptide of factor IX and a water-soluble polymer, wherein the water-soluble polymer is a non-naturally occurring saccharide, and the water-soluble polymer is bonded via an intact glycosyl linking group. A covalent bond bound to the peptide. The water-soluble polymer is poly (ether), the poly (ether) is poly (alkylene oxide), and the poly (alkylene oxide) is poly (ethylene glycol). [Selection figure] None |