| abstract |
PROBLEM TO BE SOLVED: To provide a Factor IX polypeptide and a method for using the same. The invention relates to a method of administering Factor IX, a method of administering chimeric and hybrid polypeptides comprising Factor IX, a chimeric and hybrid polypeptide comprising Factor IX; encoding such chimeric and hybrid polypeptides Polynucleotides, cells containing such polynucleotides, and methods of producing such chimeric and hybrid polypeptides using such cells. In one embodiment, a chimeric polypeptide comprising Factor IX and an FcRn binding partner (FcRn BP) at a dose of at least about 25 IU / kg is administered to a human subject at a dosing interval of about once per week or longer. A method of administering Factor IX to said subject in need thereof. [Selection figure] None |