abstract |
Anti-human IL-21 monoclonal antibody that is expressed as an autoimmune disorder and an inflammatory disorder and suppresses symptoms and biological activities associated with interleukin (IL-21) / IL-21 receptor interaction And methods of using these antibodies. Human anti-human IL-21 monoclonal antibodies and hybridomas producing them. Some of these antibodies have the ability to bind to native human IL-21 protein, recombinant mutant IL-21 protein, and / or peptide regions of human IL-21. These human anti-IL-21 antibodies are useful in the therapeutic treatment of autoimmune and inflammatory diseases, particularly diseases mediated by follicular helper T cells, B cells, TH cells, or TH17 cells. [Selection] Figure 3 |