| abstract |
Disclosed are compositions and methods for nontoxic delivery of antiprogestin. A pharmaceutical composition comprising a compound of formula (I) and a therapeutically effective amount thereof and a pharmaceutically acceptable additive. Used to treat endometriosis, dysmenorrhea, breast cancer, uterine fibroids, and endometrial hyperproliferation. [R1 is —N (CH 3) 2 or —NHCH 3; R 2 is halogen, alkyl, acyl, hydroxy, alkoxy, acyloxy, alkyl carbonate, cypionyloxy, S-alkyl or S-acyl; R 4 is H or alkyl]. [Selection figure] None |