abstract |
A method for improving the pharmacokinetics of an antigen-binding molecule, a method for increasing the number of times that an antigen-binding molecule binds to an antigen, an antigen-binding molecule with improved pharmacokinetics, and an antigen-binding that improves the number of times an antigen-binding molecule binds to an antigen Provision of molecules and methods for producing them. An antigen-binding molecule having a value of KD (pH 5.8) / KD (pH 7.4), which is a ratio of KD at pH 5.8 and KD at pH 7.4 to an antigen, of 2 or more. A method for improving the pharmacokinetics of an antigen-binding molecule by making the antigen-binding activity at pH 5.8 of the antigen-binding molecule weaker than the antigen-binding activity at pH 7.4. [Selection figure] None |