abstract |
An isolated humanized anti-C5a antibody or antigen-binding fragment thereof is provided. An isolated antibody or antigen-binding fragment thereof binds to a free C5a polypeptide, and the free C5a is a human polypeptide (hC5a) having a specific amino acid sequence, the antibody or A composition wherein the antigen binding fragment binds to the free hC5a polypeptide in vitro in the presence of a molar excess of uncleaved native human C5 with a KD of less than 1.25-10-9 M. In one aspect, the uncut native human C5 concentration is 2 to 20 times higher than the free hC5a concentration. [Selection figure] None |