| abstract |
To find an optimal glycosaminoglycan structure that produces anti-angiogenic activity based on heparanase inhibition and / or FGF growth factor inhibition mechanism. Also provided is a drug having anti-angiogenic activity that is substantially free of the typical side effects of heparin derivatives, such as anticoagulant activity. Provided are partially desulfated glycosaminoglycan derivatives, in particular heparin, especially compounds of formula (I), wherein the U, R and R 1 groups have the meanings given in the description. To do. The glycosaminoglycan derivative has anti-angiogenic and heparanase-inhibiting activity and no anticoagulant activity. [Selection figure] None |