| abstract |
PROBLEM TO BE SOLVED: To provide a mechanism related to STI-571 resistance observed in a patient administered STI-571 in CML and related cancer, and a diagnostic method and a therapeutic method. A novel gene called Mutants Associated with Resistance to STI-571 (for example, T315I Bcr-Abl), a protein encoded by the same, a diagnostic method and A useful composition for treatment and management of various cancers that express MARS. Identify molecules that bind to MARS and / or modulate its functional activity. [Selection] Figure 11 |