| abstract |
The species specificity of monoclonal antibodies is a significant obstacle in developing them as human therapeutic agents. Providing cross-species specific antibodies against CD3. A first binding domain that is part of a specific amino acid sequence and capable of binding to an epitope of a CD3 epsilon chain of human and non-chimpanzee primates, prostate stem cell antigen (PSCA), B lymphocytes Antigen CD19 (CD19), hepatocyte growth factor receptor (C-MET), endosialin, EGF-like domain 1 of EpCAM encoded by exon 2, fibroblast activation protein alpha (FAPalpha), and insulin-like growth factor A bispecific single chain antibody molecule comprising a second binding domain capable of binding to an antigen selected from an I receptor (IGF-IR or IGF-1R). [Selection figure] None |