| abstract |
A stabilized furin (eg, recombinant furin) formulation comprising a sugar, a sugar alcohol, and / or a nonionic surfactant, and a method for stably diluting the composition. (A) 8,000 U / mL to 500,000 U / mL rfurin; (b) 190 ± 10 mM pharmaceutically acceptable salt; (c) 0.5 mM to 2 mM calcium; 2) 20% sugar or sugar alcohol; (e) 10-200 ppm nonionic surfactant; and (f) 10-200 mM buffer; and (g) pH 5.5-7.5. A stabilized aqueous recombinant furin (rfurin) composition comprising: a high furin activity when stored and / or when exposed to mechanical stress compared to an unstabilized composition And a furin preparation that reduces furin aggregation while retaining the monomeric furin content. [Selection] Figure 18 |