| abstract |
Asymmetrically substituted diketopiperazine compounds for the delivery of active agents such as insulin or insulin analogs for the treatment of hyperglycemia, and drug delivery systems using the compounds. An asymmetrically substituted diketopiperazine of formula A and a drug delivery system containing the compound. [R is H or an alkyl group having 1 to 10 carbon atoms; n or m is 0 to 20; X is an amide, ester, sulfone, sulfoxide, amine, or ketone; Y is an amide, ester, acid, hydroxyl, phenol, sulfoxide. , Phosphoric acid, or thiol] [Selection figure] None |