| abstract |
Toxicity is a problem, and viloxazine HCl {(R, S) -2- (2-ethoxyphenoxy) methyl] morpholine free of impurities such as epichlorohydrin and 2-aminoethyl hydrogensulfate Providing a manufacturing method for obtaining a substantially pure API of HCl}. 2-Ethoxyphenol (1 equivalent) and epichlorohydrin (1.5 equivalent) are reacted in the presence of potassium iodide or a phase transfer catalyst to prepare high purity epoxide 1. A method for synthesizing pyroxazine, in which high purity viloxazine hydrochloride is obtained by reacting epoxide 1 with potassium hydroxide and 2-aminoethyl hydrogen sulfate to form viloxazine free base, which is then converted into hydrochloric acid. [Selection] Figure 3 |