| abstract |
Kind Code: A1 Provided is a binding component specific to interleukin 1 receptor 1 (IL-1R1), particularly an antibody molecule. A compete with IL-I and IL-1Ra for binding to IL-IRl, binding to IL-IRl in the following K D 10 pM when measured by Kinexa TM, against IL-IRl Specific isolated binding component. The binding component is useful for the treatment of disorders mediated by IL-1R1, including rheumatoid arthritis, asthma, and chronic obstructive pulmonary disease (COPD), among others. [Selection figure] None |