http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2015537212-A
Outgoing Links
Predicate | Object |
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classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N30-96 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6803 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N30-88 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N30-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N30-26 |
filingDate | 2013-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate | 2015-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | JP-2015537212-A |
titleOfInvention | Ionic strength mediated PH gradient ion exchange chromatography |
abstract | The present invention provides a method for analyzing the composition of polypeptides such as antibodies by ionic strength mediated pH gradient ion exchange chromatography. In some embodiments, the method uses a combination of a pH gradient and an ionic strength gradient to separate the polypeptide from the charge variants of the polypeptide. In some embodiments, the method uses stable ionic strength to optimize the pH gradient separation window for separating polypeptides from charge variants. Such methods are useful for analyzing polypeptides, such as antibodies, having a pI greater than 9 or less than 7. In some embodiments, the present invention provides a variety of methods for the analysis of different pi polypeptides. [Selection] Figure 4 |
isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021210662-A1 |
priorityDate | 2012-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 909.