http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2015532915-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D241-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F5-025 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F5-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F5-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F5-02 |
| filingDate | 2013-09-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2015-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2015532915-A |
| titleOfInvention | Method for producing bortezomib |
| abstract | The present invention relates to bortezomib, tert-butyl [1-({(1S) -3-methyl-1-[(3aS, 4S, 6S, 7aS) -3a, 5,5-trimethylhexahydro-] of formula (IV) 4,6-methano-1,3,2-benzodioxaborol-2-yl] butyl} amino) -1-oxo-3-phenylpropan-2-yl] carbamate and N— of formula (V) {(1S) -3-Methyl-1-[(3aS, 4S, 6S, 7aS) -3a, 5,5-trimethylhexahydro-4,6-methano-1,3,2-benzodioxaborol- An improved process for the preparation of 2-yl] butyl} phenylalanine is provided. Compound (IV) is (1R) -3-methyl-1-[(3aS, 4S, 6S, 7aR) of formula (II) in the first solvent in the presence of the first coupling agent and the first base. -3a, 5,5-trimethyl-hexahydro-4,6-methano-1,3,2-benzodioxaborol-2-yl] butan-1-amine or a salt thereof and N— of formula (III) Produced by coupling (tert-butoxycarbonyl) -L-phenylalanine, in which case the coupling step does not involve solvent exchange. Compound (V) is produced by deprotecting compound (IV) using an alcohol solution of an inorganic acid. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2020507615-A |
| priorityDate | 2012-09-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 114.