http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2015530988-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-141 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7105 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P19-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2013-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2015-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2015530988-A |
| titleOfInvention | Production and use of new therapeutic anticancer drugs |
| abstract | The present invention generally uses microribonucleic acid (microRNA, miRNA) and / or its small hairpin ribonucleic acid (shRNA) homolog / analog / derivative to design new anti-tumor and / or anti-cancer drugs, vaccines and treatments And a method. Specifically, the present invention relates to a microRNA precursor (pro-miRNA) composition produced using prokaryotic cells. When the composition is delivered to human cells, it is processed into mature miRNA effectors, causing specific silencing effects on genes that can be targeted by mir-302, and subsequently beneficial for tumor suppression and cancer treatment Has an effect. In nature, prokaryotic cells do not express or process eukaryotic miRNA precursors (pre-miRNAs). The present invention also discloses an inducible method of expressing pre-miRNAs, particularly mir-302 precursors, using a prokaryotic transcription system. Since mir-302 is a tumor suppressor for mankind, this new discovery facilitates development in the design and methods of new anticancer drugs, vaccines and / or treatments for various human tumors and cancers. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2018535684-A |
| priorityDate | 2012-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1133.